Mannitol drying is a critical pharmaceutical unit operation that removes residual moisture from crystallized mannitol (C₆H₁₄O₆), a widely used sugar alcohol excipient. Common drying method:Vacuum Rake Dryer, Fluid-bed granulator.
Mannitol drying is a critical pharmaceutical unit operation that removes residual moisture from crystallized mannitol (C₆H₁₄O₆), a widely used sugar alcohol excipient. This process transforms wet crystals into a stable, free-flowing powder essential for tablet formulation, lyophilized parenterals, and nutraceutical products.
Purpose & Importance
Moisture Control:
Achieve ≤0.5% w/w residual moisture to prevent:
Caking during storage
Maillard reactions with APIs
Microbial growth
Flowability Enhancement:
Convert sticky wet crystals into dry, free-flowing powder for direct compression.
Polymorph Stability:
Preserve the β-polymorph (most stable crystalline form) to ensure consistent compressibility and dissolution.
Sterility Assurance:
Critical for injectable-grade mannitol (e.g., lyophilized vial fillers).
Common drying method:
Vacuum Rake Dryer
ZBG Vacuum Rake Dryer is an advanced drying system that efficiently removes moisture using heat, a stirrer, and a vacuum pump.
Fluid-bed granulator
FL fluid-bed granulator is used for mixing, granulating, drying, and top-spray coating of powders in the pharmaceutical, food, and chemical industries, ideal for tablet granules, instant beverages, and seasonings.FL Fluid-bed Granulator excels in its ability to perform mixing, granulating, drying, and coating operations in a single step.
Mannitol drying bridges crystallization and final formulation, demanding precise control over temperature, airflow, and humidity to preserve its unique properties. Fluidized bed drying dominates modern production, balancing efficiency with crystalline integrity.